MOTS-C (20mg)

MOTS-C is a peptide your mitochondria produce naturally — and one of the most unusual molecules in longevity research because it doesn't come from your nuclear DNA like most proteins do. It was discovered in 2015 by researchers at the University of Southern California. Its role is metabolic signalling: it tells your cells how to handle energy, glucose, and stress. Levels decline with age, and that decline correlates with the metabolic problems that tend to accumulate as people get older — insulin resistance, reduced exercise capacity, poor energy regulation.

The 20mg vial is the better fit for longer research runs. You get twice the compound of the 10mg version, better value per milligram, and fewer interruptions from needing to reorder mid-protocol. If you already know MOTS-C is part of your research stack, the 20mg is simply more practical.

Most longevity peptides — Epitalon, GHK-Cu, SS-31 — either target gene expression, cell repair, or mitochondrial protection. MOTS-C is specifically a metabolic signal: it regulates how your body produces and uses energy at the cellular level. It's most relevant for researchers focused on metabolic health, insulin sensitivity, and exercise adaptation alongside longevity — rather than purely on skin, telomeres, or inflammation.

When cells are under metabolic stress, MOTS-C moves from the mitochondria into the cell nucleus and activates the body's master energy-regulating switch — a protein called AMPK. When AMPK is active, cells take up glucose more efficiently, burn fat more readily, and generally run more cleanly. This is the same pathway that exercise activates — and researchers believe declining MOTS-C is part of why older bodies respond less effectively to the same training stimulus than younger ones.

Animal studies have shown MOTS-C can reverse high-fat diet-induced insulin resistance, improve exercise tolerance, and counteract age-related metabolic decline. In humans, circulating MOTS-C levels are lower in people with type 2 diabetes and obesity — and decline measurably with age — supporting the idea that it plays an active protective role rather than being a passive byproduct of healthy metabolism.

MOTS-C is supplied as a lyophilized powder and should be reconstituted with bacteriostatic water (BAC water) immediately before use. Inject the BAC water slowly into the vial, directing the stream down the inside wall. Gently swirl to dissolve — do not shake. Once reconstituted, store at 2–8°C and use within 28 days. For a full step-by-step walkthrough, see our complete peptide reconstitution guide.

Store lyophilized MOTS-C vials at -20°C, away from light and moisture. After reconstitution with BAC water, refrigerate at 2–8°C and use within 28 days. Do not freeze the reconstituted solution.

MOTS-C (20mg) will be available through Aussie Peptides with fast domestic shipping to all Australian states and territories. Every vial is dispatched from within Australia — no customs delays, no international freight uncertainty. Batch-specific CoA information will be available in our CoA library.

MOTS-C (20mg) is currently available on pre-order at Aussie Peptides, with dispatch expected between 13 April 2026 and 17 April 2026. MOTS-C (20mg) is priced at $125.99 per vial at Aussie Peptides. All orders ship domestically within Australia, and batch CoAs are available in our CoA library.